Insulins and Insulin Therapy

The goal of insulin therapy for patients with diabetes is to provide coverage that most closely resembles endogenous insulin production and results in the best glycemic control without hypoglycemia. Although daytime control of hyperglycemia may be accomplished with bolus doses of rapid-acting insulin analogs, elevations in fasting glucose may remain a problem. If fasting blood glucose levels remain elevated, the basal insulin dose (intermediate or long-acting) may have to be adjusted.

Most insulins used today are recombinant DNA human insulins. Produced through genetic engineering, synthetic human insulin is "manufactured" by yeast or nonpathogenic E. coli. In recent years, pharmaceutical companies have developed several new types and formulations of insulin.

Different insulins are distinguished by how quickly they are absorbed, the time and length of peak activity, and overall duration of action. Onset, peak, and duration of action times are approximate and vary according to individual factors such as injection site, blood supply, concurrent illnesses, lifestyle, and exercise level. These factors can vary from patient to patient and can vary in any patient from day to day.

There are 5 kinds of insulins: rapid-acting, short-acting, intermediate-acting, long-acting, and combination insulins.

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Citation

Vallerand, April Hazard., et al. "Insulins and Insulin Therapy." Davis's Drug Guide, 19th ed., F.A. Davis Company, 2024. www.drugguide.com/ddo/view/Davis-Drug-Guide/109512/all/Insulins_and_Insulin_Therapy.

Vallerand AHA, Sanoski CAC, Quiring CC. Insulins and Insulin Therapy. Davis's Drug Guide. F.A. Davis Company; 2024. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/109512/all/Insulins_and_Insulin_Therapy. Accessed September 24, 2024.

Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2024). Insulins and Insulin Therapy. In Davis's Drug Guide (19th ed.). F.A. Davis Company. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/109512/all/Insulins_and_Insulin_Therapy

Vallerand AHA, Sanoski CAC, Quiring CC. Insulins and Insulin Therapy [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2024. [cited 2024 September 24]. Available from: https://www.drugguide.com/ddo/view/Davis-Drug-Guide/109512/all/Insulins_and_Insulin_Therapy.

TY - ELEC T1 - Insulins and Insulin Therapy ID - 109512 A1 - Sanoski,Cynthia A, AU - Vallerand,April Hazard, AU - Quiring,Courtney, BT - Davis's Drug Guide UR - https://www.drugguide.com/ddo/view/Davis-Drug-Guide/109512/all/Insulins_and_Insulin_Therapy PB - F.A. Davis Company ET - 19 DB - Davis's Drug Guide DP - Unbound Medicine ER -

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